Motif ID: FOX{C1,C2}.p2

Z-value: 1.639


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXC1chr6_+_1555679-0.136.2e-01Click!
FOXC2chr16_+_851583570.039.2e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74491272 5.401 ALB
albumin
chr17_-_61655915 5.319 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr9_-_74735669 4.988 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr4_+_74500748 4.826 ALB
albumin
chr3_+_134978615 4.734 TF
transferrin
chr3_-_150578023 4.429 TM4SF1
transmembrane 4 L six family member 1
chr10_+_7785347 4.068 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_-_150578103 3.985 TM4SF1
transmembrane 4 L six family member 1
chr10_+_7785360 3.782 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785331 3.710 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785290 3.356 ITIH2
inter-alpha (globulin) inhibitor H2
chr14_+_94117511 3.337 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr3_-_150578148 2.965 TM4SF1
transmembrane 4 L six family member 1
chr14_+_94117483 2.956 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr10_+_7785235 2.830 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr11_-_2113297 2.738 IGF2
insulin-like growth factor 2 (somatomedin A)
chr1_-_56750235 2.642 PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_115826481 2.620 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr2_-_188127294 2.284 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_+_189547377 2.102 COL3A1
collagen, type III, alpha 1
chr2_+_189547358 2.045 COL3A1
collagen, type III, alpha 1
chr2_+_189547323 1.985 NM_000090
COL3A1
collagen, type III, alpha 1
chr17_-_7023378 1.778 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr12_+_99391870 1.702 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr12_+_99391681 1.601 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr17_-_7023283 1.509 ASGR1
asialoglycoprotein receptor 1
chr2_-_88208650 1.450 NM_001443
FABP1
fatty acid binding protein 1, liver
chr4_-_84254912 1.442 PLAC8
placenta-specific 8
chr4_-_100359353 1.357 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr20_+_42644633 1.355 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr6_+_158358067 1.215 NM_001178088
SYNJ2
synaptojanin 2
chr14_+_94117545 1.209 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_-_84254932 1.142 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr21_-_42608531 1.115 TFF3
trefoil factor 3 (intestinal)
chr2_-_188127430 1.098 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr4_-_84254873 1.073 PLAC8
placenta-specific 8
chr9_+_123088217 1.055 GSN
gelsolin
chr3_-_116272911 1.018 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr19_-_6671585 0.914 NM_000064
C3
complement component 3
chrX_-_130250880 0.891 IGSF1
immunoglobulin superfamily, member 1
chr1_+_151867483 0.814 NM_006271
S100A1
S100 calcium binding protein A1
chr3_-_150578207 0.814 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr17_-_36347197 0.812 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr19_+_8415875 0.804 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr2_-_216008689 0.784 FN1
fibronectin 1
chr4_+_166519392 0.752 NM_001873
CPE
carboxypeptidase E
chr7_+_94123672 0.726 PEG10
paternally expressed 10
chr19_-_47723183 0.705 CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr16_+_68238460 0.703 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr7_+_134483305 0.649 NM_018295
TMEM140
transmembrane protein 140
chr14_-_93924663 0.632 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_93924873 0.623 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr8_-_13018123 0.619 NM_001164271
DLC1
deleted in liver cancer 1
chr14_+_99601498 0.608 NM_016337
EVL
Enah/Vasp-like
chr14_+_99601517 0.603 EVL
Enah/Vasp-like
chr5_+_35892747 0.552 NM_002185
IL7R
interleukin 7 receptor
chr20_+_9146036 0.540 NM_182797
PLCB4
phospholipase C, beta 4
chrX_-_130251068 0.535 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr20_+_56904042 0.532 GNAS
GNAS complex locus
chr15_-_88150823 0.530 ANPEP
alanyl (membrane) aminopeptidase
chr9_-_114520184 0.529 NM_021218
C9orf80
chromosome 9 open reading frame 80
chr8_-_17599438 0.496 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr13_+_96592051 0.467 MBNL2
muscleblind-like 2 (Drosophila)
chr11_-_74818685 0.451 KLHL35
kelch-like 35 (Drosophila)
chr16_+_80626456 0.450 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_-_3503881 0.450 LRPAP1
low density lipoprotein receptor-related protein associated protein 1
chr21_-_42608774 0.443 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr22_+_38246509 0.439 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr10_-_82039158 0.436 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr17_+_70984173 0.412 KIAA0195
KIAA0195
chr21_-_42689192 0.403 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr17_+_7563763 0.396 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr8_-_11742668 0.395


chr7_-_50596238 0.393 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr11_-_8789457 0.381 NM_139157
ST5
suppression of tumorigenicity 5
chr17_+_37967690 0.375 COASY
CoA synthase
chr5_-_111121150 0.364 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr11_+_111288686 0.355 HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr16_+_68157611 0.352 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr2_-_190635566 0.349 NM_005259
MSTN
myostatin
chrX_+_70438352 0.349 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr14_+_75141557 0.344 NM_001195283
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chrX_-_40391744 0.343 NM_144970
CXorf38
chromosome X open reading frame 38
chr11_+_1817294 0.343 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr17_+_37967617 0.340 NM_001042529
NM_001042530
NM_001042531
NM_001042532
NM_025233
COASY




CoA synthase




chr2_-_174968595 0.339 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr17_+_46176105 0.339 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr16_+_14835214 0.331 NOMO1
NODAL modulator 1
chr7_+_94123612 0.329 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr14_-_23846904 0.324 CIDEB
cell death-inducing DFFA-like effector b
chr3_-_52688768 0.321 NM_018165
NM_181042
PBRM1

polybromo 1

chr13_-_19244398 0.321 PSPC1
paraspeckle component 1
chr11_+_111288669 0.317 NM_001541
HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr8_-_11739592 0.312 CTSB
cathepsin B
chr7_-_55897938 0.307 NM_207366
SEPT14
septin 14
chrX_+_68752635 0.303 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr6_-_138862273 0.298


chr2_+_69055208 0.296 NM_019617
GKN1
gastrokine 1
chr17_+_37967702 0.291 COASY
CoA synthase
chr9_-_130683997 0.276 NM_001122671
NM_001122672
NM_004059
CCBL1


cysteine conjugate-beta lyase, cytoplasmic


chr9_+_133295297 0.272 NM_013318
PRRC2B
proline-rich coiled-coil 2B
chr8_+_70541412 0.269 NM_001128204
NM_015170
SULF1

sulfatase 1

chr9_+_123088690 0.266 GSN
gelsolin
chr4_-_3503951 0.264 NM_002337
LRPAP1
low density lipoprotein receptor-related protein associated protein 1
chr4_+_38740246 0.261 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr1_+_200246370 0.256 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr17_+_70964258 0.253 NM_014738
KIAA0195
KIAA0195
chr9_-_135922912 0.253 NM_007371
BRD3
bromodomain containing 3
chr1_-_36721010 0.249 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr10_-_7722747 0.247 ITIH5
inter-alpha (globulin) inhibitor H5
chr4_-_90197140 0.240 NM_014883
FAM13A
family with sequence similarity 13, member A
chr10_-_112668892 0.239 NM_001195304
NM_001195305
NM_001195307
BBIP1


BBSome interacting protein 1


chr10_-_98315090 0.238 TM9SF3
transmembrane 9 superfamily member 3
chr22_+_29333069 0.237 NM_000355
NM_001184726
TCN2

transcobalamin II

chr10_+_90414125 0.235 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr17_-_36346240 0.235 KRT23
keratin 23 (histone deacetylase inducible)
chr6_-_133076873 0.233 NM_004666
VNN1
vanin 1
chr4_+_120276386 0.228 NM_016599
MYOZ2
myozenin 2
chr16_+_29739256 0.227 MVP
major vault protein
chr2_+_27109341 0.224 TMEM214
transmembrane protein 214
chr20_+_56903595 0.224 GNAS
GNAS complex locus
chr16_-_74024750 0.223 NM_006324
CFDP1
craniofacial development protein 1
chr11_+_113672407 0.223 NNMT
nicotinamide N-methyltransferase
chr16_+_29739215 0.222 NM_005115
NM_017458
MVP

major vault protein

chr1_-_120413542 0.212 NOTCH2
notch 2
chr3_-_95175282 0.209 PROS1
protein S (alpha)
chr5_+_150000394 0.205 NM_001109974
NM_007286
SYNPO

synaptopodin

chr21_-_26345294 0.202


chr2_-_224612177 0.199 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chrX_-_40391610 0.197 CXorf38
chromosome X open reading frame 38
chr1_-_201422533 0.196 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr5_-_39460787 0.196 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr11_+_113672378 0.191 NNMT
nicotinamide N-methyltransferase
chr5_-_39460687 0.188 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr10_-_91092410 0.184 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr2_-_88066423 0.181 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr2_+_161701711 0.176 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr19_+_7859380 0.174 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr1_-_110735158 0.174 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr1_+_154095883 0.168 NM_152280
SYT11
synaptotagmin XI
chr17_-_33179118 0.168 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr2_+_170074457 0.166 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr2_+_73973600 0.166 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr3_-_195571748 0.165 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr4_-_159312973 0.163 FAM198B
family with sequence similarity 198, member B
chr16_-_21130368 0.162 NM_003460
ZP2
zona pellucida glycoprotein 2 (sperm receptor)
chr6_+_83834080 0.160 NM_015018
DOPEY1
dopey family member 1
chr6_+_25760352 0.159 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr16_-_70763524 0.158 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr2_-_254037 0.156 NM_001159597
NM_015677
SH3YL1

SH3 domain containing, Ysc84-like 1 (S. cerevisiae)

chr7_-_50600536 0.155 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr2_+_73973640 0.151 ACTG2
actin, gamma 2, smooth muscle, enteric
chr5_+_140454382 0.149 NM_018936
PCDHB2
protocadherin beta 2
chr6_-_52818851 0.148 NM_153699
GSTA5
glutathione S-transferase alpha 5
chr1_+_150958621 0.146 NM_001024679
C1orf68
chromosome 1 open reading frame 68
chr6_+_64414389 0.144 NM_015153
PHF3
PHD finger protein 3
chr5_+_176806401 0.143 NM_001174101
NM_030567
PRR7

proline rich 7 (synaptic)

chr1_-_229181203 0.140 TTC13
tetratricopeptide repeat domain 13
chr8_+_121526823 0.140 NM_022045
MTBP
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
chr14_+_23771464 0.140 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr9_+_111442888 0.132 NM_001037293
PALM2
paralemmin 2
chr17_+_8154864 0.132 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chrX_+_105932536 0.128 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr10_+_42953886 0.127 NM_018590
CSGALNACT2
chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr2_-_253982 0.126 SH3YL1
SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
chr22_+_16423147 0.124 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr16_-_342399 0.120 NM_003502
NM_181050
AXIN1

axin 1

chr7_-_99115454 0.113 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr2_+_238432925 0.112 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr2_-_158439868 0.112 NM_001105
ACVR1
activin A receptor, type I
chr11_+_117680504 0.109 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr15_+_97010219 0.109 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr1_+_117345894 0.108 NM_004258
CD101
CD101 molecule
chr12_-_110378240 0.108


chr5_-_59819642 0.107 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr22_+_19239221 0.107 MED15
mediator complex subunit 15
chr12_-_56200547 0.106 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr9_-_134809816 0.106 NM_000368
NM_001162426
NM_001162427
TSC1


tuberous sclerosis 1


chr12_-_54522881 0.106 NM_002429
MMP19
matrix metallopeptidase 19
chr16_-_52295214 0.105 NM_001127897
NM_015272
RPGRIP1L

RPGRIP1-like

chr11_+_61766299 0.105 NM_006551
SCGB1D2
secretoglobin, family 1D, member 2
chr1_+_158352143 0.104 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr2_+_108271526 0.103 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr13_+_51334117 0.103 NM_031290
CCDC70
coiled-coil domain containing 70
chr6_+_88026338 0.102 ZNF292
zinc finger protein 292
chr16_-_29845024 0.101 KCTD13
potassium channel tetramerisation domain containing 13
chr6_+_72982865 0.099 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr13_+_113023938 0.098 LAMP1
lysosomal-associated membrane protein 1
chr11_+_124984559 0.096 STT3A
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
chr6_+_155579788 0.095 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr1_+_242281175 0.094 NM_205768
ZNF238
zinc finger protein 238
chr14_-_23623657 0.093 NM_006177
NRL
neural retina leucine zipper
chrX_-_24575146 0.091 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr20_+_35266581 0.090 RPN2
ribophorin II
chr4_+_160408447 0.089 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr10_-_79459296 0.087 NM_007055
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr1_+_27591738 0.086 NM_005281
GPR3
G protein-coupled receptor 3
chr1_+_67404756 0.085 NM_144701
IL23R
interleukin 23 receptor
chr19_+_17527502 0.085 NM_024656
GLT25D1
glycosyltransferase 25 domain containing 1
chr14_+_23527866 0.084 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.76 1.47e-02 GO:0005576 extracellular region

Nothing significant found in function category.